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ROS build-up in CRC stimulates HIF-1, which successively generates the release of 5-fluorouracil (5-FU) via the beginning PI3K/Akt signaling

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The standard treatment regimen for patients with GBM involves maximal surgical resection followed by 6 weeks of radiotherapy and adjuvant chemotherapy with temozolomide (TMZ) (Stupp et al., 2009)