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These LSCs undergo metabolic reprogramming to develop distinct energy-dependent traits ( The rapid proliferation of tumor cells requires a large amount of energy and metabolic precursors ( To meet the need for ATP for quick multiplication, AML cells preferentially use the glycolytic pathway for energy, a characteristic of metabolic reprogramming in tumor cells known as the Warburg effect ( Because of their exceptional metabolic flexibility, AML cells can adapt their metabolism to changing dietary conditions and stress levels, allowing them to constantly produce ATP and biomolecules