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Furthermore, magnetic NPs of Ferroferric Oxide (Fe 3 O 4 ), oleic acid-coated Fe 3 O 4 , and carbon-coated Fe with different surface charges exhibited different cytotoxic effects on human hepatoma BEL-7402 cells and increased NP surface charges caused higher cytotoxicity by cell cycle arrest and inducing apoptosis (Kai et al., 2011)