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Common reasons for deficiency include: Low intake – particularly diets low in whole grains, legumes, leafy greens or animal products Gut health issues – like low stomach acid, SIBO, coeliac disease, IBD, or other factors affecting absorption Medications – such as the contraceptive pill, metformin or antacids, which can deplete B vitamins Chronic stress – increases demand for certain b vitamins, including B5 and B6 Vegan or vegetarian diets – higher risk of B12 deficiency, which can be corrected through supplementation Genetic reasons – some mutations on certain genes can increase a person’s need for B vitamins This is why I always recommend testing before supplementing

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Some researchers believe that GIP receptor activation partially offsets the nausea caused by GLP-1 stimulation, which could explain why some patients tolerate tirzepatide better than pure GLP-1 agonists despite receiving more potent appetite suppression