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Evolutionary engineering is based on miming selection mechanisms active in nature

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So, it could happen that an effective drug candidate isn’t brought into clinical studies just because the misinterpreted p K a data suggests it’s not soluble in blood, although it actually is.’ The scientists realised that something was wrong when they weren’t able to reconcile the values obtained from p K a prediction models with experimental data that had been previously compiled by the International Union of Pure and Applied and Chemistry (Iupac)